Sveučilište u Zagrebu Medicinski fakultet

Razumijevanje primjene (prednosti, nedostaci, ograničenja) molekularnih tehnika u onkologiji.

Sagledavanje i razumijevanje vrijednosti novijih otkrića (2010-2015) u području molekularne onkologije

Genetika i epigenetika raka; metilacija molekule DNA; genski upis i višestruke uloge proteina CTCF; polimorfizam promotora i aktivnost gena; modifikacije histona; kromatinska imunoprecipitacija; transkriptom stanice raka i primjena -omics metoda u molekularnoj onkologiji; micro-RNA i njihovo modeliranje; pretraživanje genske banke i drugih baza podataka; metabolizam stanice i zloćudna preobrazba; obrada seminarskih radnji (obrada zn. članaka u područjima onkologije, molekularne i kliničke, kojima se polaznici bave u svakodnevnom radu). Pisani ispit – test.

 

• Montezuma D, Henrique RM, Jeronimo C. Altered expression of histone deacetylases in cancer. Crit Rev Oncog 2015;20(1-2):19-34.
• Vahid F, Zand H, Nosrat-Mirshekarlou E, Najafi R, Hekmatdoost A. The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review. Gene 2015; 562(1):8-15.
• McGuire A, Brown JA, Kerin MJ. Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring. Cancer Metastasis Rev 2015;34(1):145-55.
• Hamm CA, Costa FF. Epigenomes as therapeutic targets. Pharmacol Ther 2015; doi: 10.1016/j.pharmthera.2015.03.003.
• Ma X, Wang YW, Zhang MQ, Gazdar AF. DNA methylation data analysis and its application to cancer research. Epigenomics 2013;5(3):301-16.
• Yang Y, Dong X, Xie B, Ding N, Chen J, Li Y, Zhang Q, Qu H, Fang X. Databases and Web Tools for Cancer Genomics Study. Genomics Proteomics Bioinformatics 2015;13(1):46-50.
• Ong CT, Corces VG. CTCF: an architectural protein bridging genome topology and function. Nat Rev Genet 2014;15(4):234-46.
• Augoff K, Hryniewicz-Jankowska A, Tabola R. Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer. Cancer Lett 2015;358(1):1-7.
• Cooks T, Harris CC, Oren M. Caught in the cross fire: p53 in inflammation. Carcinogenesis 2014;35(8):1680-90.
• Joosse SA, Gorges TM, Pantel K. Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol Med 2014;7(1):1-11.
• Madhamshettiwar Piyush B, Maetschke SR, Davis MJ, Reverter A, and Ragan MA INsPeCT: INtegrative Platform for Cancer Transcriptomics. Cancer Informatics 2014;13 59-66.

Predavanja, seminari, vježbe 

Pisani ispit - test